Childhood Respiratory Illnesses | Health Trend in Early Childhood – September 2025

Trend

  • Respiratory viruses, including influenza (flu), COVID-19, and respiratory syncytial virus (RSV) pose a significant threat to children’s health. There were 270 pediatric deaths during the 2024-2025 flu season. Most people showing up in emergency departments right now are children, mainly because of the return to school, which expands social networks and creates more opportunities for illnesses to spread.

Explanation

Currently, COVID-19 continues to climb and is on track to surpass the peak of last winter’s wave. As the respiratory virus season approaches, flu, COVID, and RSV are expected to circulate at the same time and play significant roles in the months ahead. Healthcare providers, parents and caregivers require clear, accurate, and trustworthy information to support informed decisions. 

Emergency room visits for Covid-19. Source: CDC 

Annotated on 8.25.25 by Your Local Epidemiologist | Katelyn Jetelina | Substack

Impact

Updated! “Vaccinated or Unvaccinated: What You Should Know” 

The Vaccine Education Center Vaccine Education Center | Children’s Hospital of Philadelphia recently released volume 2 (Summer 2025) of the Special Topics sheet, Vaccinated or Unvaccinated: What You Should Know. This sheet was updated to include more details about what families with unvaccinated individuals should be doing to protect them, particularly those families opting out of vaccinations. The sheet is also available in Spanish. 

Respiratory illnesses in children are common and include influenza (flu), pneumonia, bronchiolitis, and croup, leading to significant complications and hospitalizations. Respiratory Illnesses | Respiratory Illnesses | CDC 

Influenza (flu): Seasonal flu can lead to severe respiratory illness in children.  Flu Resource Center | Flu Resource Center | CDC 

Children with chronic health conditions at greater risk for complications from flu 

Some children are at especially high risk for developing severe disease or complications from the flu, such as children with lung, heart, or kidney disease, an immune system condition, cancer, diabetes, some blood diseases or conditions of the muscular or central nervous system. The Flu: What Parents Need to Know – HealthyChildren.org 

Pneumonia: the most common cause of hospitalization in children, often caused by a virus, such as the respiratory syncytial virus (RSV) 

RSV (Respiratory Syncytial Virus): can be dangerous for infants  

Infants younger than 6 months of age with RSV can become very sick and may need to be hospitalized. RSV can also cause bronchiolitis (inflammation of the small airways in the lungs) and pneumonia (infection of the lungs). 

  • CDC recommends all babies be protected from severe RSV by one of two immunization options: A maternal RSV vaccine given to the mother during pregnancy or an RSV antibody given to the baby. Most babies do not need both.  Immunizations to Protect Infants | RSV | CDC 

Mycoplasma pneumoniae 
Respiratory infections caused by the bacteria Mycoplasma pneumoniae remain elevated as indicated by emergency department visits and positive tests. M. pneumoniae infections can sometimes be severe, causing what’s known as “walking pneumonia.” About Mycoplasma pneumoniae Infection | M. pneumoniae | CDC. 

Pertussis (Whooping Cough) 
Whooping cough is very contagious and can spread easily from person to person. Babies younger than 1 year are at highest risk of severe disease and complications. The best way to prevent complications from whooping cough is to get vaccinated. Learn more: About Whooping Cough | Whooping Cough | CDC. 

Bronchiolitis: a viral infection that affects the small airways in the lungs, causing wheezing and respiratory distress, primarily seen in infants and young children  

Croup: characterized by a barking cough, croup is usually caused by a virus and affects children under 5 years old 

CDC tracks other disease-causing bacteria and viruses here: Other Respiratory Illnesses Going Around | Respiratory Illnesses | CDC 

Action

Recommendations from the CDC about Preparing for Respiratory Virus Season: Talking with Patients About Respiratory Virus Season | Respiratory Illnesses | CDC 

  • Immunization, timely testing, and treatment against influenza (flu), COVID-19, and respiratory syncytial virus (RSV) remains the best way to protect against severe disease. 

(Visual aids by CDC. Accessed 8.26.25) 

Preventing Spread of Respiratory Viruses When You’re Sick: Preventing Spread of Respiratory Viruses When You’re Sick | Respiratory Illnesses | CDC 

(Infographic from CDC can be enlarged. Accessed 8.26.25) 

Credible Resources

  • American Academy of Pediatrics (AAP):  
  • The Vaccine Integrity Project (Vaccine Integrity Project – CIDRAP) convened a nationwide team of experts in epidemiology, infectious diseases, and research methodology to conduct a comprehensive and independent analysis of vaccine safety and efficacy data for influenza, COVID-19, and RSV immunizations. The studies reviewed found no significantly elevated safety risks from US-licensed immunizations for these conditions. 

References

May 8, 2025, Morbidity and Mortality Weekly Report (MMWR):  

Interim Evaluation of Respiratory Syncytial Virus Hospitalization Rates Among Infants and Young Children After Introduction of Respiratory Syncytial Virus Prevention Products — United States, October 2024–February 2025 | MMWR 

Research finding: In the first RSV season with widespread availability of RSV prevention products (maternal vaccine and nirsevimab), RSV-associated hospitalization rates among infants were lower than in pre-pandemic seasons. A report released in the May 8, 2025, MMWR* demonstrated that in 2024–25, RSV hospitalization rates were 45-52% lower in infants younger than 3 months old and 28-43% lower in infants younger than 8 months old compared to 2018-2020 seasons before product introduction. 

Health Trends in Early Childhood

Childhood Respiratory Illnesses | September 2025

About Child Trends in Early Childhood

Welcome to Health Trends in Early Childhood, the monthly release from The Pennsylvania Key, focused on trending health issues related to children birth to age five and their families and caregivers.

Each month, find information about a recent health trend, learn why it is important, discover the impact it has on children, their families and caregivers, and the community, as well as actions we all can take to ensure the health and well-being of children in our communities. Also, find reliable resources to learn more about the issue.

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Disclaimer: This is the most updated information at release time. The information in Health Trends is not a Pennsylvania regulatory requirement for early childhood providers. Pennsylvania early childhood providers with regulatory requirements should contact their Cert rep or the Bureau of Certification.